玉山黑猪两种头型遗传机制的初步解析

doi:10.11843/j.issn.0366-6964.2018.08.003

Abstract

Abstract:

The aim of this study was to identify candidate genes affecting the two head types(long-pointed head and short head) in Yushan Black pigs through conducting a genome-wide association study(GWAS) and a genome-wide scan for the selection signatures. Twenty-four pigs with long-pointed head and 12 pigs with short head were selected from the national conservation farm of Yushan Black pigs and were genotyped using Porcine SNP 60K BeadChips. The Fst value of each SNP was calculated to detect signatures of genetic differentiation between the two groups of pigs. Meanwhile, case-control GWAS and linkage disequilibrium(LD) analysis were performed to define confidence intervals and candidate genes based on Fst. The results showed that the most significant signature of genetic differentiation was located on Sus Scrofa chromosome(SSC) 10, and a genome-wide significant locus within the same region was also detected by GWAS. The most likely interval of this locus was defined by the LD block analysis, about 290 kb (from 11.76 to 12.05 Mb) on SSC10. By applying genetic differentiation analysis, genome-wide association study and linkage disequilibrium (LD) analysis, we speculated that candidate genes for head types were RAB3GAP2 and IASR2 in Yushan Black pigs. The findings will contribute to reveal the genetic basis of phenotypic changes in head types in Chinese indigenous pigs.

CLC Number:

S828.2

WANG Cheng-bin, WANG Xiao-peng, ZHENG Xiao-ming, CHEN Hao, ZHANG Jun-jie, GUO Yuan-mei, DING Neng-shui. A Study of the Genetic Mechanisms for Two Head Types in Yushan Black Pigs[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(8): 1585-1593.

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A Study of the Genetic Mechanisms for Two Head Types in Yushan Black Pigs

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